Dual CXCR4 and E-Selectin Inhibitor, GMI-1359, Shows Anti-Bone Metastatic Effects and Synergizes with Docetaxel in Prostate Cancer Cell Intraosseous Growth
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منابع مشابه
Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia
BACKGROUND Sickle cell anemia is an inherited disorder of hemoglobin that leads to a variety of acute and chronic complications. Abnormal cellular adhesion, mediated in part by selectins, has been implicated in the pathophysiology of the vaso-occlusion seen in sickle cell anemia, and selectin inhibition was able to restore blood flow in a mouse model of sickle cell disease. METHODS We perform...
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normal 0 false false false en-us x-none ar-sa background: prostate cancer is one of the most common cancer types both in western and eastern countries, involving mostly elder men. the mechanisms underlying the prostate cancer development remain unclear. prostate-specific antigen (psa) is the only well accepted marker for prostate cancer diagnosis and prognosis. the diagnosis and treatment of pr...
متن کاملCorrection: Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia
Copyright: ß 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...
متن کاملBone and Prostate Cancer Cell Interactions in Metastatic Disease. Authors
Institutions 1. School of Medicine, University of Queensland, Brisbane, Queensland, Australia 2. Department of Urology, Princess Alexandra Hospital, Brisbane, Queensland, Australia 3. School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia 4. Centre for Diabetes and Endocrine Research, Princess Alexandra Hos...
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ژورنال
عنوان ژورنال: Cells
سال: 2019
ISSN: 2073-4409
DOI: 10.3390/cells9010032